Ademola Lookman was on target for Fulham who suffered a Premier League defeat as Edinson Cavani’s equaliser and Paul Pogba’s magical stunner sent Manchester United back to the top of the league.
Lookman scored inside five minutes of the game but it was cancelled out by Cavani’s 21st minute equalizer.
Then Pogba gave United the lead with a spectacular left-footed drive midway through the second half claimed a vital three points that saw Ole Gunnar Solskjaer’s side reclaim top spot from rivals Manchester City.
Fulham threw everything at United in search of an equaliser but fell agonisingly short as Ruben Loftus-Cheek squandered two second-half chances before substitute Aleksandar Mitrovic saw a last-gasp header deflect inches wide off Eric Bailly.
The victory means United have now played 17 games unbeaten on the road for the first time since their treble-winning season of 1999.
Next, United host Liverpool in the fourth round of the FA Cup on Sunday before entertaining Sheffield United in the Premier League on Wednesday.
Fulham host Burnley in the fourth round of the FA Cup on Sunday before travelling to Brighton in the Premier League on Wednesday.